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Depression symptoms keep people from living life to its fullest and, in some cases, can be debilitating, leading to dangerous levels of hopelessness. That’s why finding effective treatment options is so important for those with the symptoms of depression. Among the innovative treatments available are Spravato® (esketamine) and ketamine, both known for their potential to alleviate symptoms of depression. At Columbia Associates, we specialize in providing advanced mental health services, including interventional treatments like Spravato® treatment for individuals with treatment-resistant depression.

What Is Ketamine?

Ketamine is a medication traditionally used as an anesthetic in medical settings. In recent years, its off-label use for treating depression has gained attention due to its rapid and potent antidepressant effects. Administered via IV or intramuscular injection, ketamine works by modulating glutamate activity in the brain, which can lead to a significant reduction in depressive symptoms within hours.

What Is Spravato® (Esketamine)?

Spravato® is the brand name for esketamine, a derivative of ketamine specifically approved by the FDA for treatment-resistant depression. Unlike traditional ketamine, Spravato® is administered as a nasal spray under the supervision of a healthcare professional at clinics like Columbia Associates. It is used in conjunction with an oral antidepressant and offers a fast-acting alternative for those who have not responded to other treatments.

Spravato® vs. Ketamine: A Comparison

Since both of these drugs are used to fight the effects of depression, it’s worth taking a closer look at their similarities and differences:

Spravato® (Esketamine)

• Approval – Spravato® is FDA-approved specifically for treatment-resistant depression. This medication has undergone rigorous testing for safety and efficacy for depression treatment.
• Administration – Nasal spray administered under medical supervision in a clinical setting. This can be more convenient and less invasive than the intravenous infusion that’s required for Ketamine.
• Mechanism – This medication works by targeting the NMDA receptor, which is thought to play a role in mood regulation. Esketamine is thought to be more potent and effective at lower doses compared to Ketamine.
• Controlled setting – Spravato’s® specific protocols require monitoring by healthcare professionals to manage any potential side effects and ensure client safety during and after administration.
• Side effects – Common side effects include dizziness, nausea, and dissociation.

Ketamine

• Approval – Ketamine is FDA-approved as an anesthetic but not explicitly for depression treatment. It is commonly used off-label for treatment-resistant depression and other psychiatric conditions.
• Administration – Typically administered via intravenous infusion in a controlled clinical environment for 40 minutes to an hour.
• Mechanism – Similar to Spravato®, it targets the NMDA receptor but is a different isomer of the compound. This modulation is believed to play a key role in its antidepressant effects.
• Controlled setting – Continuous monitoring of vital signs is conducted throughout the infusion process. This includes heart rate, blood pressure, respiratory rate, and oxygen saturation.
• Side effects – Common side effects may include dizziness, blurred vision, increased heart rate or blood pressure, and dissociative experiences. These symptoms are usually temporary and resolve within an hour after treatment.

The decision between Spravato® or ketamine use for depression treatment is best made in consultation with a mental health professional who can assess your individual needs and recommend the most suitable treatment option. Factors such as previous treatment attempts, severity of symptoms, potential side effects, and personal preferences should all be considered.

Accessibility and Cost

Some additional factors to consider in Spravato® vs. ketamine are accessibility and cost. Ketamine treatments are widely available at specialized treatment centers but can be costly due to the need for multiple sessions and the lack of insurance coverage for off-label use. In contrast, Spravato® is FDA-approved and thus more likely to be covered by insurance, making it a more accessible option for many clients. At Columbia Associates, we accept most major insurance plans, ensuring that our clients receive the care they need without undue financial burden.

Many clients have reported significant improvements in their depressive symptoms with both ketamine and Spravato® treatments. Anecdotal experiences highlight the profound impact these medications can have on individuals who have not found relief with traditional antidepressants. The ability to quickly alleviate symptoms often leads to enhanced quality of life and renewed hope for those with depression.

Contact Columbia Associates Today for Depression Treatment

Choosing between Spravato® and esketamine use for depression treatment depends on individual needs and circumstances. Both options offer rapid relief for treatment-resistant depression, but their administration methods, side effects, and accessibility differ. Consulting with experienced therapists and psychiatric professionals at Columbia Associates can help determine the best course of action tailored to your unique situation.

If you’re ready to take the next step in your mental health journey, click here to reach out to our team of empathetic mental health care experts. For existing clients, please click here and find your office location to contact your office directly.